{"id":14256,"date":"2025-07-28T10:29:09","date_gmt":"2025-07-28T10:29:09","guid":{"rendered":"https:\/\/wagmc.ug.edu.gh\/staging\/?page_id=14256"},"modified":"2025-07-28T10:29:49","modified_gmt":"2025-07-28T10:29:49","slug":"diabetes-kidney-disease","status":"publish","type":"page","link":"https:\/\/wagmc.ug.edu.gh\/staging\/diabetes-kidney-disease\/","title":{"rendered":"Diabetes &#038; Kidney Disease"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"14256\" class=\"elementor elementor-14256\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-45337361 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"45337361\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b3ed83c\" data-id=\"b3ed83c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-60f7f233 elementor-widget elementor-widget-heading\" data-id=\"60f7f233\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Diabetes &amp; Kidney Disease<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2f19d43d elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"2f19d43d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3b431e26\" data-id=\"3b431e26\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4582562e elementor-widget elementor-widget-heading\" data-id=\"4582562e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">The centre currently focuses on kidney disease in the H3Africa Kidney Disease Research Network. Its primary goal is to conduct genomics, clinical and translational research on the most prevalent forms of chronic kidney disease (CKD), expand and support a well-trained cadre of African researchers and physician scientists to conduct CKD research. <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4d9d5dc7\" data-id=\"4d9d5dc7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ffecc9e elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"ffecc9e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7d0e8dda\" data-id=\"7d0e8dda\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8b37219 elementor-hidden-tablet elementor-hidden-phone elementor-widget elementor-widget-spacer\" data-id=\"8b37219\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6755675e elementor-widget elementor-widget-text-editor\" data-id=\"6755675e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In 2019, the network focused on a cohort study that was initiated in 2018. This research was formulated to identify genetic risk factors of CKD among Africans. Estimates indicate\u00a0more than three million African-Americans and greater than 50 million African Blacks have CKD due to clinically defined nephropathies (from hypertension, diabetes mellitus, sickle disease, etc.) and glomerula nephritis. A significant fraction of these will progress to end-stage-renal disease (ESRD) which is a harbinger of imminent death in the African setting due to the scarcity of dialysis or kidney transplantation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6cfcbc16\" data-id=\"6cfcbc16\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43ee228a elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"43ee228a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f1ac0ce\" data-id=\"f1ac0ce\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-79981cfa elementor-hidden-tablet elementor-hidden-phone elementor-widget elementor-widget-spacer\" data-id=\"79981cfa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4bce3cde elementor-widget elementor-widget-image\" data-id=\"4bce3cde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"258\" src=\"https:\/\/wagmc.ug.edu.gh\/staging\/wp-content\/uploads\/2025\/06\/h3-1024x258.png\" class=\"attachment-large size-large wp-image-12294\" alt=\"\" srcset=\"https:\/\/wagmc.ug.edu.gh\/staging\/wp-content\/uploads\/2025\/06\/h3-1024x258.png 1024w, https:\/\/wagmc.ug.edu.gh\/staging\/wp-content\/uploads\/2025\/06\/h3-300x76.png 300w, https:\/\/wagmc.ug.edu.gh\/staging\/wp-content\/uploads\/2025\/06\/h3-768x193.png 768w, https:\/\/wagmc.ug.edu.gh\/staging\/wp-content\/uploads\/2025\/06\/h3.png 1199w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5325b830\" data-id=\"5325b830\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5415dfba elementor-widget elementor-widget-text-editor\" data-id=\"5415dfba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>This H3Africa Kidney Disease Research Network cohort study is the first adequately powered prospective cohort study to both identify the genetic determinants and characterize the phenotype for kidney disease progression in Sub Sahara-Africa. The Aims of the research are:<\/em><\/p><p>\u2022 To evaluate the independent contribution of risk variants in the APOL1 genes to the progression of clinically defined nephropathies among 2,500 HIV-negative African Blacks.<br \/><br \/>\u2022 To elucidate gene-environment interactions (G-E) between APOL1 variants and infections) on glomerular disease and evaluate the incidence, histopathological spectrum and the natural history of biopsy-confirmed glomerular diseases in 1,500 HIV-negative African Blacks from various SSA countries and regions.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7d9a7f19 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"7d9a7f19\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-566802a8\" data-id=\"566802a8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5339bf47 elementor-widget elementor-widget-text-editor\" data-id=\"5339bf47\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The impact of this research is that it will enable us to: (1) know how APOL1 risk variants impact kidney disease progression; (2) identify the modifiable risk factors for kidney disease progression; (3) determine how APOL1 renal variants impact the risks and outcomes of non-HIV infection-associated glomerular nepheritis; (4) obtain novel insights into the histopathological spectrum and natural history of glomerular diseases in Blacks; and (5) create a research data and specimen repository that would serve as a platform for basic research, translational studies and therapeutic trials of kidney disease in Blacks.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7448e659 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"7448e659\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-34bd002\" data-id=\"34bd002\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-327e58e5 elementor-widget elementor-widget-text-editor\" data-id=\"327e58e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>As of December 2019, the following achievements have been made:<\/em><\/p><p>\u2022 The total recruitment for Accra and Kumasi is 587<br \/>\u2022 Renal biopsies have been performed on 76 participants<br \/>\u2022 DNA have been isolated, quantified and stored, and have undergone quality control assays; the amelogenin and SRY Y assays for gender determination, Alu1 repeat, hemoglobin S and C determination, using the initial polymerase chain reaction and Ligase detection reaction based amplification.\u00a0<\/p><p><em>In another collaborative study involving 12 academic medical centres\/university teaching hospitals in four\u00a0\u00a0African countries (Cameroon-1; Ghana-2; Nigeria-7; South Africa-1; and Tanzania-1), the following achievements were made in 2019 with respect to recruitment:<\/em><\/p><p>\u2022 Sickle Cell Disease-\u00a0197<br \/>\u2022 C and L-HIV- \u00a08<br \/>\u2022 Nephrotic syndrome- 23<\/p><p>Our ongoing plans are to ensure ethical recruitment and good quality control of data acquisition and laboratory studies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-178cdc65 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"178cdc65\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3f146db8\" data-id=\"3f146db8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45087b5c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"45087b5c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Diabetes &amp; Kidney Disease The centre currently focuses on kidney disease in the H3Africa Kidney Disease Research Network. Its primary goal is to conduct genomics, clinical and translational research on the most prevalent forms of chronic kidney disease (CKD), expand and support a well-trained cadre of African researchers and physician scientists to conduct CKD research. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-14256","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wagmc.ug.edu.gh\/staging\/wp-json\/wp\/v2\/pages\/14256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wagmc.ug.edu.gh\/staging\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wagmc.ug.edu.gh\/staging\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wagmc.ug.edu.gh\/staging\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/wagmc.ug.edu.gh\/staging\/wp-json\/wp\/v2\/comments?post=14256"}],"version-history":[{"count":3,"href":"https:\/\/wagmc.ug.edu.gh\/staging\/wp-json\/wp\/v2\/pages\/14256\/revisions"}],"predecessor-version":[{"id":14262,"href":"https:\/\/wagmc.ug.edu.gh\/staging\/wp-json\/wp\/v2\/pages\/14256\/revisions\/14262"}],"wp:attachment":[{"href":"https:\/\/wagmc.ug.edu.gh\/staging\/wp-json\/wp\/v2\/media?parent=14256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}